ABSTRACT
Risk assessment for fast growing burden of cardiovascular diseases is very important and difficult. As a response to this challenge, in particular, genetic risk factors which potentially modify risk, we conducted a survey of primary data registry of Shiraz Heart Study on integration and application of family history data in prevention of cardiovascular disorders. This study is a longitudinal cohort project to be extended from subpopulations of different job groups to the community. Parental family history of MI, diabetes mellitus [DM], hyperlipidemia [HPL], hypertension [HTN] was reported more frequently among females than males. Histories of MI, DM, HPL, and HTN in both parents were respectively positive in 2.6%, 2%, 4.6%, and 7.9% of the participants. Odd ratios [OR] for risk of MI from family history of MI were 2.7; risk of DM from family history of DM 4.5; risk of HPL from family history of HPL 2.04; and risk of HTN from family history HTN 4.7. Also, family history of MI modifies risk of HPL [OR=1.7, P<0.0001]; and family history of DM modifies risk of HPL [OR=2.04, P<0.0001]. Our primary result shows potent application of family history data in risk assessment of cardiovascular outcome. In particular, HTN appears as a silent and leading risk modifier. In regard to the course of continuing Shiraz Heart Study integration of family history of risk factors crucial in public health we suggest to adopt a network of electronic health records from the [Health House] to the [Heart House]
ABSTRACT
Classic phenylketonuria [PKU] is a rare metabolic disorder that results from a deficiency of a liver enzyme known as phenylalanine hydroxylase [PAH]. In this study, we researched about PKU epidemiological factors and health quality of patients after the neonatal screening program. Neonatal screening for PKU was conducted by one neonatal screening center in Fars Province, in Shiraz Paramedical University. All Fars infants must refer only to this center, in which a heel prick blood sample of each infant was collected at 72 hours postnatal on to standard filter paper and asked questions from the children's parent's and the doctor examined the patients receiving phenylalanine- free milk through examining the children's development. PKU was screened by Fluorometric method. Totally of 70477 newborns screened for PKU, 15- cases of PKU detected with an incidence of 1:4698. In "Eghlid", that is a city in Fars Province. The prevalence of the disease is 1:382 of newly born babies. The frequency of familial marriage in these children's parents is 86.6%. Twenty nine percent of them were observed among those who had married their close relatives. Mean rate of normal development in PKU patients was 95%.Consanguineous marriage is a major cause in that pattern particular in Iranian. The treatment of PKU after newborn screening is used. With special diet in above of 90% newborn is satisfactory. Now screening should be executed for all of family that they have familial history of PKU in Iran
Subject(s)
Humans , Phenylketonurias/diagnosis , Neonatal Screening , Consanguinity , Intellectual DisabilityABSTRACT
T4 and T3, two major hormones of thyroid gland, are responsible for regulation of "basal metabolism" in the body. Thyroid function is regulated primarily by variation in the pituitary TSH. In this study, about four hundred individuals were considered from four Iranian populations. They were selected randomly in their cities; Shiraz, Mashhad, Rasht, and Ilam. Essential family information was asked to achieve native belonging of each person to related population. Blood specimens were collected, by separating serums, freezed serums were transferred immediately to Tehran for hormone assay. Assay of T4 and T3 concentrations was carried out by 'RIA-magnetic' kits and of TSH by 'IRMA-magnetic' kits. Analysis of variance has been taken into account among days of sampling in each city to calculate mean concentrations for T4, T3 and TSH. Analysis of association between age and hormones concentrations in each population was done by the regression and the correlation tests. Significant differences were detected at T4 mean concentration in each of these populations [P=0.0001]. Differences for T3 mean concentration were observed only between Shiraz and Mashhad [P=0.021]; and Shiraz and Rasht [P=0.003]. By increasing age of individuals, there were also a negative correlation at mean concentrations of T4 and T3 in Ilam [P=0.022], and Mashhad [P=0.016] respectively. According to these data, and specificity of environmental and genetic factors to each popualtions, specific 'normal reference' of T4 and T3 homones should be considred for each of these populations. Correlation study of mean concentrations of these hormones and genetic variations of some critical genes such as thyroid peroxidase [TPO] and iodothyronine deiodinase can open new window of epidimiology among Iranian popualltions